Manipulation of magnetic particles in conduits for the propagation of domain walls
Manipulation of magnetic particles in conduits for the propagation of domain walls
P. Vavassori, R. Bertacco, M. Cantoni, M. Donolato, M. Gobbi, S. Brivio, and D. Petti
Priority date:
Granted:
Japan (17/05/2013), USA (04/11/2014), Europe (24/06/2015)
OWNERSHIP
CIC nanoGUNE
USAGE
Novel tools and approaches for on-chip single-molecule and cell remote manipulation.
DESCRIPTION
- We demonstrated that nano-sized magnetic domain walls (the so-called constrained magnetic domain walls, i.e., boundaries between regions with opposite magnetization), which can be generated and manipulated by remote weak magnetic fields in lithography-defined magnetic nanostrips, can be used as nano-magnetic tweezers for trapping and manipulating magnetic nano- and micro-particles in suspension.
- We designed and realized exemplary devices on functional substrates suitable for bio- and microfluidic applications. With these devices, we then demonstrated the remote, nm-scale precision, and robust manipulation of bio-entities (proteins and cells) labeled with magnetic particles in solution for magnetic field-controlled remote and automatized on-chip operation (see M. Donolato et al., Advanced Materials DOI: 10.1002/adma.201000146 (2010)).
- We have proposed an application for molecular sequencing that exploits this approach for nanoparticles magnetic manipulation integrated into plasmonic nano-membranes (see N. Maccaferri et al., Appl. Phys. Lett. DOI: 10.1063/5.0046245 (2021))
ADVANTAGES
- Remote on-chip operation
- Robustness
- Versatility
- Force control from fN to nN
- Manipulation at nm-scale of individual or large populations of beads
- Integrable in flexible platforms
- Combinable with detection systems (including optical)
- Small volumes handling (ml), gentle operations (minimal loss of sample)